Every day our body is challenged from outside with various foreign bodies, radiation as well as free radicals that are produced inside our cells as the waste product of different metabolic reactions. Free radicals are also known as the Reactive Oxygen Species (ROS). Accumulation of free radical gradually causes oxidative stress and plays an important role in the development of chronic and degenerative diseases like cardiovascular diseases, cataract, neurodegenerative diseases and aging. Different external factors and internal free radicals are as harmful as any other infectious agents to our body.
Inflammatory response occurs, when there is injury in the tissue due to any kind of infection or trauma. The chemical released from the damaged cells into the surrounding tissues and cause pain, swelling and redness (Inflammatory response). Inflammation is necessary after any kind of injury and infection, but inflammatory process itself is tissue damaging during healing and repairing process, and if the inflammation process goes to long it becomes a physiological condition. It has also been suggested that when inflammatory cells stay too long in blood vessels, they promote the build-up of plaque. Cancer, diabetes, asthma, meningitis, osteoporosis, Inflammatory Bowel Diseases all are chronic inflammatory diseases. Over time, chronic inflammation and ROS is responsible for DNA damage and lead to some forms of cancer too.
Although, our body naturally has several mechanisms to fight against oxidative stress and to prevent and repair damage from free radicals. In addition to that assisting our body with some natural supplement in RDI concentration which will act as antioxidants, anti-inflammatory and anti-cancer to maintain a healthy body is never a bad idea.
Curcuma longa (Curcumin extract) is the phytochemical component in turmeric. Turmeric is an Indian spice that are used regularly in Indian cuisine, and got attention from both medicine and scientific world long ago. Curcumin has been found to help in the management of the inflammation and muscle soreness, thus enhance the recovery and quality of the life. In several research paper, curcumin has been found to target multiple molecules and thus work at the cellular level to support several health welfares. Tumor Necrosis Factor-α (TNF-α), is one of the major inflammatory mediators in numerous diseases, and it is the master regulator of Nuclear Factor- κβ (NF-κβ). NF-κβ and NF-κβ regulated genes have been found to be involved in several disease condition. Curcumin is one of the active ingredients that is involved in the downregulation or blocking the activation of NF-κβ. Curcumin demonstrates free radical-scavenging activity. It has been shown to scavenge various Reactive Oxygen Species (ROS) produced by macrophages (including superoxide anions, hydrogen peroxide and nitrite radicals). Curcumin has the potent wound healing property. It increases serum activities of antioxidants such as superoxide dismutase (SOD). Curcumin also helps in increasing the death receptors (DRs) on cells and hence apoptosis. Furthermore, curcumin is a lipophilic compound, which makes it an efficient scavenger of peroxyl radicals, therefore, like vitamin E, curcumin is also considered as a chain-breaking antioxidant. The major problem associated with ingestion of curcumin, is its poor bioavailability.
Piper nigrum (Black pepper extract) has the active compound Piperine, which is helpful to relieve digestion problem, nausea, headache and has anti-inflammatory properties. Black pepper extract also enhances the absorption of the active ingredients.
BENEFITS OF PERCUMINTM
- Natural anti-inflammatory ingredient
- Lowers the risk of brain diseases and improves the brain function
- Lowers the risk of heart diseases
- Anti-oxidant property helps to prevent the body from the damage of free radical
- Helps to prevent cancer at the molecular level
- Helps to lower the total cholesterol, LDL and triglycerides level
- Piperine increases the bioavailability of curcumin and also helps in digestion.